The NWA biopic, produced by Dr Dre and Ice Cube, was expected to make around half that figure, having cost $29m to make.
Exit polls showed audiences were evenly divided between genders, while 46% were African-American and 23% white.
Dr Dre’s soundtrack, Compton, is also top of the UK and US album charts.
The album is his first studio record in 16 years.
Ice Cube’s son, O’Shea Jackson Jr., plays his father in the movie which tells the story of the band’s rise to fame and takes its title from their debut album, released in 1988.
“It really struck a chord with audiences. It’s a story that is resonating right now,” said Paul Dergarabedian, senior media analyst with box office tracker Rentrack.
“It was one of those records that was an important work and a very important expression of a particular viewpoint.